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International Journal of Periodontics & Restorative Dentistry
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Int J Periodontics Restorative Dent 25 (2005), No. 3     27. May 2005
Int J Periodontics Restorative Dent 25 (2005), No. 3  (27.05.2005)

Page 265-275


Attachment of Periodontal Ligament Cells onto Various Antibiotics-Loaded GTR Membranes
Hung, Shan-Ling/Lin, Yi-Wen/Chen, Yen-Ting/Ling, Li-Jane
This study compared the natures of various guided tissue regeneration (GTR) membranes impregnated with amoxicillin or tetracycline. Whether the antibiotics-loaded membranes enhance the attachment of the periodontal ligament cells in the presence of oral pathogens was further analyzed. S mutans and A actinomycetemcomitans diminished the attachment of periodontal ligament cells onto the membranes as evaluated by SEM analysis. These bacterial effects on cellular attachment could be reversed using the antibiotics-loaded membranes. The information obtained in this study is valuable for the future application of antibiotics-loaded membranes during GTR therapy.