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International Journal of Periodontics & Restorative Dentistry
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Int J Periodontics Restorative Dent 26 (2006), No. 2     4. Apr. 2006
Int J Periodontics Restorative Dent 26 (2006), No. 2  (04.04.2006)

Page 134-141, PubMed:16642902


Immunohistochemical Evaluation of Inflammatory Mediators in Failing Implants
Konttinen, Yrjö T./Ma, Jian/Lappalainen, Rejo/Laine, Pekka/Kitti, Uula/Santavirta, Seppo/Teronen, Olli
It was hypothesized that peri-implant tissue around loosening dental implants may contain cytokines with a potential to regulate osteoclasts. Peri-implant and/or gingival samples from loosened implants, chronic periodontitis (CP), and normal controls (n = 10 samples in each group) were analyzed using immunohistochemical staining to observe tumor necrosis factor alpha (TNF-α), interleukin 1-alpha (IL-1α), IL-6, platelet-derived growth factor A (PDGF-A), and transforming growth factor alpha (TGF-α). These cytokines were found in foreign-body giant cells, macrophages, fibroblasts, and epithelial cells. TNF-α, IL-1α, and IL-6 were increased (P < .05; unpaired t test) in peri-implantitis and CP, whereas PDGF-A and TGF-α were not. In conclusion, cytokines with a potential to activate osteoclasts were found in both peri-implantitis and CP, but the cytokine profiles differed in that IL- 1α was the most prevalent cytokine in the former and TNF-α was the most common in the latter. These cytokines may contribute to peri-implant bone loss/loosening by stimulating formation and activity of osteoclasts and might be an amenable target for local therapies with cytokine modulators.