We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
International Journal of Periodontics & Restorative Dentistry



Forgotten password?


Int J Periodontics Restorative Dent 26 (2006), No. 4     24. July 2006
Int J Periodontics Restorative Dent 26 (2006), No. 4  (24.07.2006)

Page 321-327, PubMed:16939013

Clinical and Histologic Evaluation of a Mineralized Block Allograft: Results from the Developmental Period (2001 2004)
Keith, J. Daulton/Petrungaro, Paul/Leonetti, Joseph A./Elwell, Charles W./Zeren, Karl J./Caputo, Chris/Nikitakis, Nikolaos/Schöpf, Christoph/Warner, Michael M.
This article reports on a multicenter evaluation of a novel, sterile, antigen-inactivated, mineralized block allograft in humans during a 3-year developmental period. Consecutive partially edentulous patients (n = 73) with severe localized ridge defects (n = 82) were treated with the material. After 4 to 6 months of healing, tapered screw implants were placed in the grafted bone and subsequently restored. Patients were monitored 25 to 36 months after prosthetic restoration. A biopsy was taken of one patient and submitted for histomorphometric analysis. Block allograft survival was 93% at 12 months, and resorption ranged from none (69%) to slight (0 to 2 mm) (31%) for all surviving allografts. Seven block allografts failed and were removed because of improper contouring, prosthesis impingement, and/or infection. The sites were successfully re-treated and restored with dental implants. Soft tissue dehiscence was successfully treated in seven other sites. Implant survival was 99%. One implant failed without allograft failure. It was replaced with a larger-diameter implant, treated with guided bone regeneration, and subsequently restored. Histomorphometric analysis showed rapid incorporation of the allograft at 6 months without inflammation or necrosis. The block allografts were more technique-sensitive than autografts, which necessitated meticulous surgical technique and follow-up. Short-term results for the block allografts indicated a high degree of predictability, but long-term follow-up is needed.