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International Journal of Periodontics & Restorative Dentistry



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Int J Periodontics Restorative Dent 28 (2008), No. 5     25. Sep. 2008
Int J Periodontics Restorative Dent 28 (2008), No. 5  (25.09.2008)

Page 461-467, PubMed:18990997

Root Coverage with Cultured Gingival Dermal Substitute Composed of Gingival Fibroblasts and Matrix: A Case Series
Murata, Masashi / Okuda, Kazuhiro / Momose, Manabu / Kubo, Kentarou / Kuroyanagi, Yoshimitsu / Wolff, Larry F. / Yoshie, Hiromasa
Cultured gingival dermal substitute (CGDS), composed of gingival fibroblasts and matrix and fabricated using tissue-engineering techniques, has been used for root coverage procedures. Fourteen sites from four patients with >= 2 mm of Miller Class I or II facial gingival tissue recession were treated. The autologous CGDS sheet, prepared prior to surgical treatment, was grafted over the teeth with gingival recession and then covered with a coronally positioned flap. Vertical and horizontal recession was measured at baseline (prior to the surgical procedure) and 13 to 40 weeks (average: 30.7 ± 9.6 weeks) after surgery. The average vertical and horizontal root coverage after surgery was 79.1% ± 25.7% and 75.2% ± 31.4%, respectively. Moreover, there was a significant increase of keratinized and attached gingival tissue at the final clinical evaluation compared with preoperative measurements (P < .05). These results demonstrate CGDS as a promising grafting material for use with root coverage procedures in periodontal therapy.