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International Journal of Periodontics & Restorative Dentistry
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Int J Periodontics Restorative Dent 32 (2012), No. 2     16. Mar. 2012
Int J Periodontics Restorative Dent 32 (2012), No. 2  (16.03.2012)

Page 195-202, PubMed:22292149


Impact of Recombinant Platelet-Derived Growth Factor BB on Bone Regeneration: A Study in Rabbits
Thoma, Daniel S. / Jung, Ronald E. / Hänseler, Patrick / Hämmerle, Christoph H. F. / Cochran, David L. / Weber, Franz E.
The aim of this study was to test whether recombinant human platelet-derived growth factor BB (rhPDGF-BB) enhances bone regeneration in combination with ß-tricalcium phosphate (ß-TCP) granules or deproteinized bovine bone mineral (DBBM) compared to empty defects and ß-TCP granules alone. Four titanium cylinders were placed on the external cortical plates of seven rabbits' calvaria and randomly allocated to one of four groups: (1) empty, (2) ß-TCP, (3) ß-TCP + rhPDGF-BB, and (4) DBBM + rhPDGF-BB. The mean area of bone regeneration was 13.9% ± 8.4% (empty), 24.0% ± 14.8% (ß-TCP), 37.1% ± 8.9% (ß-TCP + rhPDGF-BB), and 64.4% ± 5.4% (DBBM + rhPDGF-BB), with the greatest bone regeneration noted for DBBM + rhPDGF-BB (P < .01). The fraction of bone substitute material varied between 48.3% ± 9.3% (DBBM + rhPDGF-BB), 53.1% ± 10.6% (ß-TCP + rhPDGF-BB), and 58.0% ± 14.8% (ß-TCP). rhPDGF-BB combined with DBBM showed the greatest potential to enhance bone regeneration.