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International Journal of Periodontics & Restorative Dentistry



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Int J Periodontics Restorative Dent 33 (2013), No. 5     15. Aug. 2013
Int J Periodontics Restorative Dent 33 (2013), No. 5  (15.08.2013)

Page 567-573, doi:10.11607/prd.1745, PubMed:23998152

A Clinical Investigation of Demineralized Bone Matrix Putty for Treatment of Periodontal Bony Defects in Humans
Banjar, Arwa Ahmed / Mealey, Brian L.
The goal of this study was to evaluate the effectiveness of demineralized bone matrix (DBM) putty, consisting of demineralized human bone allograft matrix in a carrier of bovine collagen and alginate, for the treatment of periodontal defects in humans. Twenty subjects with at least one site having a probing depth ≥ 6 mm and radiographic evidence of bony defect depth > 3 mm were included. The infrabony defects were grafted with DBM putty bone graft. The following clinical parameters were assessed at baseline and 6 months posttreatment: probing depth (PD), gingival recession (GR), and clinical attachment level (CAL). Bone fill was evaluated using transgingival probing and standardized radiographs taken at baseline and 6 months posttreatment. The 6-month evaluation showed a significant PD reduction of 3.27 ± 1.67 mm and clinical attachment gain of 2.27 ± 1.74 mm. Bone sounding measurements showed a mean clinical bone defect fill of 2.93 ± 1.87 mm and a mean radiographic bone fill of 2.55 ± 2.31 mm. The use of DBM putty was effective for treatment of periodontal bony defects in humans. Significant improvement in CAL, PD, and bone fill was observed at 6 months compared to baseline.