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International Journal of Periodontics & Restorative Dentistry
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Int J Periodontics Restorative Dent 35 (2015), No. 3     28. Apr. 2015
Int J Periodontics Restorative Dent 35 (2015), No. 3  (28.04.2015)

Page 324-333, doi:10.11607/prd.2378, PubMed:25909520


Tissue Engineering for Lateral Ridge Augmentation with Recombinant Human Bone Morphogenetic Protein 2 Combination Therapy: A Case Report
Mandelaris, George A. / Spagnoli, Daniel B. / Rosenfeld, Alan L. / McKee, James / Lu, Mei
This case report describes a tissue-engineered reconstruction with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ ACS) + cancellous allograft and space maintenance via Medpor Contain mesh in the treatment of a patient requiring maxillary and mandibular horizontal ridge augmentation to enable implant placement. The patient underwent a previously unsuccessful corticocancellous bone graft at these sites. Multiple and contiguous sites in the maxilla and in the mandibular anterior, demonstrating advanced lateral ridge deficiencies, were managed using a tissue engineering approach as an alternative to autogenous bone harvesting. Four maxillary and three mandibular implants were placed 9 and 10 months, respectively, after tissue engineering reconstruction, and all were functioning successfully after 24 months of follow-up. Histomorphometric analysis of a bone core obtained at the time of the maxillary implant placement demonstrated a mean of 76.1% new vital bone formation, 22.2% marrow/cells, and 1.7% residual graft tissue. Tissue engineering for lateral ridge augmentation with combination therapy requires further research to determine predictability and limitations.