Int J Periodontics Restorative Dent 36 (2016), No. 6 14. Oct. 2016
Int J Periodontics Restorative Dent 36 (2016), No. 6 (14.10.2016)
Online Article, Page 88-94, doi:10.11607/prd.2830, PubMed:27740646
Online Article: The Effect of Osteopontin and an Osteopontin-Derived Synthetic Peptide Coating on Osseointegration of Implants in a Canine Model
Fiorellini, Joseph P. / Glindmann, Sven / Salcedo, Jairo / Weber, Hans-Peter / Park, Chang-Joo / Sarmiento, Hector L.
Osteopontin (OPN) and an OPN-derived synthetic peptide, OC-1016, have demonstrated their potential to enhance osseointegration in vitro. The purpose of this study was to evaluate bone-to-implant contact (BIC) and surrounding bone density (BD) of implants coated with either recombinant human OPN (rhOPN) or OC-1016 as compared with noncoated titanium plasma sprayed (TPS) surface in a canine model. Histomorphometric analysis revealed that at 4 weeks, %BIC and %BD of coated implants were significantly higher than those of noncoated TPS implants. At 12 weeks, %BIC of coated implants was also significantly higher than that of noncoated implants; however, there was no statistically significant difference in %BD. The rhOPN and OC-1016 were concluded to be capable of significantly accelerating the early stage of osseointegration and bone healing around implants.