We are using cookies to implement functions like login, shopping cart or language selection for this website. Furthermore we use Google Analytics to create anonymized statistical reports of the usage which creates Cookies too. You will find more information in our privacy policy.
OK, I agree I do not want Google Analytics-Cookies
International Journal of Periodontics & Restorative Dentistry
Login:
username:

password:

Plattform:

Forgotten password?

Registration

Int J Periodontics Restorative Dent 36 (2016), No. 6     14. Oct. 2016
Int J Periodontics Restorative Dent 36 (2016), No. 6  (14.10.2016)

Online Article, Page 88-94, doi:10.11607/prd.2830, PubMed:27740646


Online Article: The Effect of Osteopontin and an Osteopontin-Derived Synthetic Peptide Coating on Osseointegration of Implants in a Canine Model
Fiorellini, Joseph P. / Glindmann, Sven / Salcedo, Jairo / Weber, Hans-Peter / Park, Chang-Joo / Sarmiento, Hector L.
Osteopontin (OPN) and an OPN-derived synthetic peptide, OC-1016, have demonstrated their potential to enhance osseointegration in vitro. The purpose of this study was to evaluate bone-to-implant contact (BIC) and surrounding bone density (BD) of implants coated with either recombinant human OPN (rhOPN) or OC-1016 as compared with noncoated titanium plasma sprayed (TPS) surface in a canine model. Histomorphometric analysis revealed that at 4 weeks, %BIC and %BD of coated implants were significantly higher than those of noncoated TPS implants. At 12 weeks, %BIC of coated implants was also significantly higher than that of noncoated implants; however, there was no statistically significant difference in %BD. The rhOPN and OC-1016 were concluded to be capable of significantly accelerating the early stage of osseointegration and bone healing around implants.