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International Journal of Periodontics & Restorative Dentistry
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Int J Periodontics Restorative Dent 37 (2017), No. 1     20. Dec. 2016
Int J Periodontics Restorative Dent 37 (2017), No. 1  (20.12.2016)

Page 79-86, doi:10.11607/prd.2656, PubMed:27977821


A Possible Link Between Rheumatoid Arthritis and Periodontitis: A Systematic Review and Meta-analysis
Tang, Qingqin / Fu, Haitao / Qin, Baodong / Hu, Zhide / Liu, Yaoting / Liang, Yan / Zhou, Lin / Yang, Zaixing / Zhong, Renqian
Previous studies have shown that patients with rheumatoid arthritis (RA) have a higher susceptibility to periodontitis, but the results of individual studies remain controversial. The aim of the present meta-analysis was to comprehensively evaluate the association between RA and periodontitis. A systematic literature search was conducted in PubMed and EMBASE. Data were extracted using standardized forms, and odds ratios (OR) with 95% confidence intervals (CI) were calculated for each study. Pooled data were estimated by fixed- and randomeffects models if appropriate. Eight case-control studies were included in the present study. Study size ranged from 104 to 151,569 participants. The prevalence of periodontitis in RA patients ranged from 15.5% to 100%, compared with 10.0% to 82.1% in controls. In group 1 (control) and group 2, the heterogeneity was 38% and 11%, respectively. Using fixed-effects analysis, the overall pooled estimates of the ORs for periodontitis were 4.68 (95% CI: 3.11-7.05) and 1.28 (95% CI: 1.24-1.33) in groups 1 and 2, respectively. This meta-analysis indicates that RA was significantly associated with increased overall risk of periodontitis.