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International Journal of Periodontics & Restorative Dentistry
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Int J Periodontics Restorative Dent 37 (2017), No. 3     21. Apr. 2017
Int J Periodontics Restorative Dent 37 (2017), No. 3  (21.04.2017)

Page 393-401, doi:10.11607/prd.2888, PubMed:28196153


Periodontal Regenerative Therapy of Intrabony Defects Using Deproteinized Bovine Bone Mineral in Combination with Collagen Barrier Membrane: A Multicenter Prospective Case-Series Study
Irokawa, Daisuke / Okubo, Nobuki / Nikaido, Masahiko / Shimizu, Hiroyasu / Konobu, Hiroyuki / Matsui, Tokuo / Fujita, Takahisa / Goto, Hiroaki / Takeuchi, Takahiro / Ishii, Yoshihito / Saito, Atsushi
This multicenter prospective case series study aimed to evaluate the outcome of periodontal regenerative therapy using a deproteinized bovine bone mineral (DBBM) in combination with a collagen barrier (CB) in the treatment of intrabony defects. A total of 36 nonsmoking patients with chronic periodontitis were recruited in five centers in Japan. All patients had at least one intrabony defect of ≥ 3 mm. The surgical procedures included access for debridement using a papilla preservation technique. Defects were filled with DBBM and covered with CB. Clinical evidence after 6 months supported the effectiveness of the combination therapy in the treatment of intrabony defects.