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International Journal of Periodontics & Restorative Dentistry
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Int J Periodontics Restorative Dent 38 (2018), No. 1     5. Jan. 2018
Int J Periodontics Restorative Dent 38 (2018), No. 1  (05.01.2018)

Page 51-58, doi:10.11607/prd.3425, PubMed:29240205


Regenerative Treatment of Periodontal Intrabony Defects Using Autologous Dental Pulp Stem Cells: A 1-Year Follow-Up Case Series
Aimetti, Mario / Ferrarotti, Francesco / Gamba, Mara Noemi / Giraudi, Marta / Romano, Federica
The present case series aimed to explore the potential clinical benefits of the application of dental pulp stem cells (DPSCs) in the regenerative treatment of deep intrabony defects. A total of 11 isolated intrabony defects in 11 chronic periodontitis patients were accessed with a minimally invasive flap and filled with DPSCs loaded on a collagen sponge. A tooth requiring extraction for impaction or malpositioning was used as an autologous source for DPSCs. An average clinical attachment level gain of 4.7 ± 1.5 mm associated with a residual mean probing depth (PD) of 3.2 ± 0.9 mm and remarkable stability of the gingival margin was observed at 1 year. Complete pocket closure (PD ≤ 3 mm) was achieved in 63.6% of the experimental sites. Clinical outcomes were supported by the radiographic analysis showing a bone fill of 3.6 ± 1.9 mm.