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International Journal of Periodontics & Restorative Dentistry



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Int J Periodontics Restorative Dent 39 (2019), No. 3     14. June 2019
Int J Periodontics Restorative Dent 39 (2019), No. 3  (14.06.2019)

Page 371-379, doi:10.11607/prd.3980, PubMed:30986287

Bone Tissue Responses to Zirconia Implants Modified by Biomimetic Coating Incorporated with BMP-2
Teng, Fei / Zheng, Yuanna / Wu, Gang / Beekmans, Bart / Wismeijer, Daniel / Lin, Xingnan / Liu, Yuelian
This study aimed to histologically investigate the bone tissue response to zirconia implants functionalized with a biomimetic calcium phosphate (CaP) coating incorporated with bone morphogenetic protein-2 (BMP-2). Zirconia implants coated with biomimetic CaP were prepared with and without BMP-2. Untreated zirconia implants served as a control. These three groups of implants were placed randomly in the mandibles of six beagle dogs (n = 6). Three months later, samples were harvested for histomorphometric analysis. The present study showed that the application of a biomimetic CaP coating incorporated with BMP-2 enhanced the peri-implant osteogenesis for zirconia implants.